尿癌在现场:诊断和管理方面的进步
Gabriele Ricciardi1, Pietro Tralongo2, Francesco Pierconti3
1Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Messina, Italy; Multi-Specialist Clinical Institute for Orthopaedic Trauma Care (COT), 98124 Messina, Italy.
Clinical genitourinary cancer
|December 21, 2025
概括
尿路癌 in situ (CIS) 是一种侵略性且难以诊断的癌症. 新的治疗方法正在出现的患者不响应Bacillus Calmette-Guérin (BCG) 疗法,提供希望超出激进的囊切除术.
科学领域:
- 尿瘤学 尿瘤学
- 癌症诊断 癌症诊断 癌症诊断
- 治疗策略 治疗策略
背景情况:
- 泌尿道本位癌 (CIS) 是一种高度的,侵袭性的非肌肉侵入性尿道癌.
- 由于非特异性症状和与良性疾病重叠,诊断具有挑战性.
- 卡尔梅特-盖林菌 (BCG) 是标准的,但往往导致不响应的疾病,需要替代品.
研究的目的:
- 审查目前关于尿路生物学,诊断和治疗的证据.
- 突出管理CIS的挑战和未来方向.
- 探索用于个性化治疗的新型治疗策略和生物标志物.
主要方法:
- 对CIS的诊断技术和治疗策略的文献综述.
- 对新出现的分子和免疫相关生物标志物的分析.
- 综合关于CIS管理的当前证据.
主要成果:
- 通过窄带成像和光动力学诊断,诊断准确度得到改善.
- 新型疗法包括免疫检查点抑制剂,热化学疗法,基因疗法,IL-15超激活剂和色病毒.
- 生物标志物在预测治疗反应和指导个性化护理方面表现有前途.
结论:
- 尿路CIS需要改进的诊断和治疗方法.
- 新兴的策略为BCG不响应的疾病提供了替代方案,可能减少囊切除的需要.
- 由生物标志物指导的个性化管理是未来的关键方向.
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