身体构成与初级开放角眼的风险之间的关联
Jianqi Chen1, Yue Xiao1, Xiaohong Chen1
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
American journal of ophthalmology
|December 21, 2025
概括
较大的腿部脂肪与原发性开角玻璃眼 (POAG) 的风险较低有关. 身体组成,不仅仅是体重指数,影响POAG风险和眼内压力 (IOP).
科学领域:
- 眼科医生 眼科 眼科
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 身体质量指数 (BMI) 与初级开角玻璃眼 (POAG) 的关联不一致.
- 体重指数 (BMI) 不区分脂肪和肌肉质量或捕捉身体组成的分布.
- 特定的身体成分指标对POAG风险的影响在很大程度上仍未得到研究.
研究的目的:
- 调查身体组成 (脂肪和肌肉质量分布) 与POAG风险之间的关联.
- 检查身体组成和眼内压力 (IOP) 之间的关系.
主要方法:
- 一项使用英国生物库数据的综合横截面和队列研究 (88,123名IOP参与者,291,983名POAG发病率).
- 生物阻抗分析估计了手臂,干部和腿部的脂肪和肌肉质量,以身高正常化.
- 与共变量调整的考克斯模型估计了POAG发病率的危险比率 (HR),线性回归评估了与IOP的关联.
主要成果:
- 腿部脂肪量增加,以腿部脂肪指数 (LFI) 和腿部脂肪与肌肉比率 (FMR) 表示,显著与POAG风险降低相关 (HRs < 1,P < .01).
- 肌肉质量和POAG发生率之间没有发现显著的关联.
- 更大的脂肪质量与更高的IOP (AFI,LFI,TFI的正β系数) 有关.
- 较大的腿部肌肉指数 (LMI) 和干部肌肉指数 (TMI) 与较低的IOP (负β系数) 有关.
结论:
- POAG风险受到身体组成模式的影响,特别是脂肪分布.
- 保持健康的身体组成,以足够的腿部脂肪为特征,可能在减轻POAG风险方面发挥作用.
- 身体成分提供了对POAG风险的更细致的了解,而不是单独的BMI.
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