全球负担,风险因素,致病生物和抗生素敏感性模式在细菌角膜炎
Rohan Bir Singh1, Uday Pratap Singh Parmar2, Fasika Woreta3
1Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, MA, USA; Division of Ophthalmology and Visual Sciences, Adelaide Medical School, University of Adelaide, South Australia, Australia.
细菌性角膜炎 (BK) 占全球所有传染性角膜炎病例的近一半. 预防策略应侧重于创伤和隐形眼镜卫生,并针对MRSA和Pseudomonas进行向治疗.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 传染性角膜炎是全球视力障碍的重要原因之一.
- 细菌性角膜炎 (BK) 是一种主要的亚型,需要了解其全球负担和特征.
研究的目的:
- 系统地审查和对全球BK流行情况进行元分析.
- 确定BK.的常见微生物原因,危险因素和抗生素敏感性模式.
主要方法:
- 在主要数据库 (PubMed,Scopus等) 中进行系统搜索. 截至 2022 年 7 月.
- 包括观察性研究与微生物学确认的BCK和抗生素敏感性数据.
- 随机效应的元分析,以聚合流行率和风险因素和易感性的描述性综合.
主要成果:
- 全球BK的总流行率为44% (95%CI:39-49%),区域差异很大.
- 格拉姆阳性细菌占主导地位 (72%),其中主要物种包括Staphylococcus epidermidis,Streptococcus pneumoniae,Staphylococcus aureus和Pseudomonas aeruginosa. 这些细菌是最常见的.
- 主要的危险因素是创伤 (44%) 和隐形眼镜的使用 (23%);观察到高易感的菌素 (格拉姆阳性) 和aminoglycosides/cephalosporins (格拉姆阴性),但较低的基诺易感性和显著的MRSA率 (~20%) 被注意到.
结论:
- 在全球范围内,细菌性角质炎占传染性角质炎病例的很大一部分.
- 强调预防创伤和改善隐形眼镜卫生至关重要.
- 经验性治疗策略应考虑覆盖MRSA和Pseudomonas aeruginosa由于耐药性模式.
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