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Updated: May 13, 2026

Process Development for the Production and Purification of Adeno-Associated Virus AAV2 Vector using Baculovirus-Insect Cell Culture System
10:31

Process Development for the Production and Purification of Adeno-Associated Virus AAV2 Vector using Baculovirus-Insect Cell Culture System

Published on: January 13, 2022

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多参数过程优化用于高产量AAV2载体生产,使用缩放式多平行生物反应器系统和高通量分析工具

Nazgul Wagner1, Jonas Austerjost1, Julia Niemann1

  • 1Sartorius Stedim Biotech GmbH, August-Spindler-Straße 11, Göttingen 37079, Germany.

Journal of biotechnology
|December 21, 2025
PubMed
概括

使用生物反应器优化腺相关病毒 (AAV) 生产,揭示了温度变化显著提高功能性AAV产量. 批处理过程的效率增加了两倍,而 perfusion 过程的效率增加了三倍以上,从而提高了整体效率.

关键词:
腺相关病毒的病毒.生物制造 生物制造 生物制造基因治疗的基因疗法高通量分析工具的分析工具.多平行生物反应器系统.

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