精神分裂症患者的时间平面中的结构不对称性:元分析
Jette Borawski1, Marietta Papadatou-Pastou2, Jutta Peterburs3
1Department of Psychology, Medical School Hamburg, Hamburg, Germany; ICAN Institute for Cognitive and Affective Neuroscience, Medical School Hamburg, Hamburg, Germany.
Neuroscience and biobehavioral reviews
|December 21, 2025
概括
这一元分析揭示了与对照组相比,精神分裂症患者的显著非典型的平面时 (PT) 不对称性和左 PT 尺寸缩小. 这些发现突出了与精神分裂症相关的结构性大脑差异.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 神经解剖学是一个神经解剖学.
背景情况:
- 关于精神分裂症中平面时 (PT) 非对称性的存在不一致的发现.
- PT对于听觉和语言处理至关重要,与精神分裂症症状相关.
研究的目的:
- 综合现有的关于精神分裂症结构性PT不对称性的文献,使用元分析.
- 为了比较精神分裂症患者与健康对照者的PT不对称性.
主要方法:
- 在多个数据库中使用PRISMA指南进行系统的文献搜索 (2024年).
- 包括28项研究,共1409名参与者 (760名精神分裂症患者,649名对照患者).
- 对PT不对称性的MRI/CT数据的随机效应元分析.
主要成果:
- 在精神分裂症患者中发现了显著的非典型PT不对称性.
- 与对照组相比,在精神分裂症患者中观察到左侧PT大小的显著减少.
- 没有发现显著的缓解作用;研究质量中等至高.
结论:
- 精神分裂症与非典型的结构平面时间不对称性有关.
- 减少左侧PT尺寸是精神分裂症潜在的神经生物学标志物.
- 这些发现有助于理解精神分裂症的神经生物学基础.
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