一个系统的审查和对常规白血细胞度的元分析在有饮食障碍的人
Johanna Keeler1, Can Xu2, Rebecca Morris2
1Centre for Research in Eating and Weight Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, the United Kingdom of Great Britain and Northern Ireland; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LVR University Hospital Essen, Virchowstrasse 174, 45147 Essen, Germany.
Neuroscience
|December 21, 2025
概括
白血细胞 (WBC) 计数在神经性厌食症 (AN) 中由于营养不良而较低,但随着体重恢复正常化. 神经性吃 (BN) 显示白细胞数量基本不变,只有基细胞减少.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 精神病学是一个精神病学.
背景情况:
- 饮食障碍显著影响身体健康,影响像白细胞 (WBCs) 这样的免疫参数.
- 改变饮食模式和饮食障碍中的补偿行为有助于这些免疫变化.
研究的目的:
- 系统地审查和元分析饮食障碍患者的白细胞度.
- 为了比较WBC在神经性厌食症 (AN) 和神经性嗜食症 (BN) 与健康对照 (HC) 中的横截面和纵向计数.
主要方法:
- 来自三个数据库的38项研究的系统审查和元分析.
- 在AN与HC和BN与HC中对WBC和亚型的横截面分析.
- 在重量恢复的不同阶段,对AN中白细胞的纵向分析.
主要成果:
- 在截面上,与HC相比,AN患者的白血球,淋巴细胞,基细胞,单细胞和中性粒细胞的数量较低;埃索诺菲尔细胞没有变化.
- BN患者的白血球计数与HC相比基本不变,基细胞减少.
- 在长度上,AN中的白血球随着体重恢复而增加,当BMI接近18.5公斤/米时正常化;淋巴细胞保持不变.
结论:
- 减少的白细胞和亚型可能是由于营养不良,需要足够的重量恢复正常化.
- 在BN患者中,白细胞度通常不受影响.
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