在三阴性乳腺癌中,海斯乳酸化将代谢重编程与染色素-免疫交叉桥架相结合
Jingyuan Li1, Ziyi Li2, Xiaoping Zhang3
1Chongqing Key Laboratory of Human Embryo Engineering and Precision Medicine, Center for Reproductive Medicine, Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, Chongqing, China; Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Molecular Biology Laboratory of Respiratory Disease, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
激素乳酸化是一种新的代谢修饰,驱动了侵袭性三阴性乳腺癌 (TNBC) 的进展和免疫逃避. 针对这一过程为TNBC患者提供了一个有前途的治疗策略.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 代谢过程中的代谢.
背景情况:
- 三阴性乳腺癌 (TNBC) 是一种具有攻击性的亚型,其特点是代谢失调和免疫逃避.
- 增强的葡萄糖分解和代谢重编程与TNBC恶性瘤有关.
- 希斯乳酸化是一种从乳酸中获得的新型修饰,它连接了新陈代谢和基因调节.
研究的目的:
- 为了调查质母乳化在促进TNBC进展中的作用.
- 探索其对瘤免疫微环境的影响.
- 为了确定基因素乳化作为TNBC的潜在治疗点.
主要方法:
- 单细胞基因组学 单细胞基因组学
- 多个omics的分析分析.
- 临床队列研究 临床队列研究
- 抑制糖解的方法
主要成果:
- 血糖分解和乳酸脱酶A (LDHA) 的升高与TNBC中预后不佳和基因组乳酸化增加相关.
- 抑制糖溶解会降低基因组的乳糖化,抑制瘤生长和转移.
- 基因素乳化增强了染色质的可访问性和基因转录,与H3K27ac合作重新编程表观遗传格局.
- 局部特异性乳化 (H3K9la,H3K14la,H3K18la) 调节不同的恶性特征并影响免疫细胞状态.
结论:
- 基因素乳化是关键的调解者,将新陈代谢重编程 (糖解) 与TNBC中的基因调节联系起来.
- 它在瘤进展和调节瘤免疫微环境中发挥着关键作用.
- 基斯乳基化是改善TNBC管理和患者治疗结果的有希望的治疗标.
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