免疫功能的发育起源:产前情绪与婴儿免疫细胞基因表达有关
Gabrielle R Rinne1, Christine Dunkel Schetter2, Susan Jackman3
1Department of Psychology, University of California, Los Angeles, CA, USA; Department of Psychology, University of Southern California, Los Angeles, CA, USA.
Brain, behavior, and immunity
|December 21, 2025
概括
母亲产前抑郁症状会影响婴儿的免疫路径,影响炎症和抗病毒基因表达. 这表明,怀孕期间母亲的心理健康与婴儿免疫发育之间存在联系.
科学领域:
- 围产期心理健康问题
- 免疫学 免疫学 免疫学
- 发育生物学是发展生物学.
背景情况:
- 产前环境通过胎儿的适应,显著影响后代的终身健康.
- 后代的免疫系统发育是连接产前暴露与以后健康结果的关键途径.
研究的目的:
- 研究母亲产前抑郁和焦虑症状与婴儿免疫基因表达之间的关联.
- 为了确定在怀孕期间受到母亲心理健康影响的特定免疫路径.
主要方法:
- 对118对母婴婴儿进行长度研究.
- 在整个怀孕期间通过采访评估母亲的抑郁和焦虑症状.
- 在产后1个月左右,使用RNA测序 (RNAseq) 从干血斑点分析婴儿基因表达.
主要成果:
- 孕产妇的抑郁症状与婴儿前炎性 (NF-κB通路) 基因表达增加和抗病毒 (IRF通路) 基因表达减少相关.
- 母亲焦虑症状显示出抗病毒基因表达减少的趋势,但考虑到抑郁症状后,这并不显著.
结论:
- 产前抑郁症状可能会通过炎症和抗病毒途径改变婴儿免疫系统的发展.
- 这些发现强调了母亲心理健康对婴儿免疫功能和随后的健康轨迹的潜在影响.
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