感觉运动大脑功能的异常与腰部疼痛的慢性有关
Jo Armour Smith1, Rongwen Tain2, Kelli G Sharp3
1Department of Physical Therapy, Chapman University, Irvine, California, USA.
NeuroImage
|December 21, 2025
概括
与腰部疼痛 (LBP) 相关的大脑变化,即使疼痛不存在,也可能持续存在. 大脑功能和姿势控制中的这些神经差异可以作为LBP的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 生物力学 生物力学
背景情况:
- 不适应性大脑可塑性可能导致慢性腰部疼痛 (LBP).
- 在一些患有LBP的个体中观察到变化的腰腰部姿势控制.
- 之前的工作建立了一个MRI兼容的腿抬起范式,以评估姿势控制期间的大脑活动.
研究的目的:
- 为了比较年轻成年人与没有LBP病史的大脑功能.
- 在LBP中调查大脑功能,疼痛和姿势控制之间的关系.
- 为了确定与LBP相关的神经功能障碍的潜在生物标志物.
主要方法:
- 功能磁共振成像 (fMRI) 评估了在抬腿任务期间的大脑激活.
- 电肌图和地面反应力量化姿势控制.
- 招募了55名患有LBP病史 (无症状) 的参与者和30名健康对照者.
主要成果:
- 与对照人群相比,患有LBP的个体在角回旋和后带状皮层中表现出更大的激活.
- 异常的姿势控制与右侧中心前环和左侧后带带皮层激活的增加有关.
- 更糟糕的疼痛特征与左后带带皮层激活减少和右角环激活增加有关.
结论:
- 与运动相关的脑功能改变在LBP早期存在,并在症状发作之间持续存在.
- 这些神经变化与LBP的临床特征有关.
- 研究结果表明,LBP与疼痛相关的循环中功能障碍的潜在生物标志物会影响病理生理学.
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