转移的清晰细胞精液囊癌伪装成高度前列腺癌
Mohamed M Khamis1, Morgan Lynelle Walters2, Heide A Rodgers3
1Department of Medicine, Mercy Hospital St Louis, St. Louis, Missouri, USA MOHAMED.KHAMIS@mercy.net.
BMJ case reports
|December 21, 2025
概括
一种罕见的转移性透明细胞精液囊腺癌,模仿前列腺癌,突出诊断挑战. 尽管PSA正常,但这种癌症需要先进的病理学和成像来准确诊断和治疗.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 前列腺癌的诊断可能是具有挑战性的,特别是非典型的表现.
- 正常的前列腺特异性抗原 (PSA) 水平可能会使前列腺腺癌的诊断复杂化.
- 精液囊腺癌是一种罕见的恶性瘤,有可能侵入前列腺.
研究的目的:
- 报告转移的清晰细胞精液囊腺癌病例,诊断延迟.
- 要突出先进成像和免疫组织化学在罕见的生殖尿道恶性瘤的诊断实用性.
- 讨论这种罕见疾病的临床过程和治疗方法.
主要方法:
- 临床表现审查一个患有血质和血精的患者.
- 诊断工作包括前列腺特异性抗原 (PSA) 水平和前列腺特异性膜抗原-正子发射断层扫描 (PSMA-PET) 扫描.
- 专家病理学审查与全面的免疫组织化学 (PAX8,CA-125,HNF1Beta,前列腺标志物).
主要成果:
- 最初的诊断是格里森8前列腺腺癌,尽管PSA正常.
- PSMA-PET扫描显示出一个意想不到的肺病变,确认为转移性腺癌.
- 病理学证实了转移的清晰细胞精液囊腺癌侵入前列腺.
- 患者接受了治疗,包括PARP抑制剂,税,基化疗和脑转移的放射性手术.
结论:
- 转移的透明细胞精液囊腺癌可以模仿前列腺癌,需要彻底的诊断评估.
- 高级成像 (PSMA-PET) 和专家病理学与免疫组织化学对于诊断罕见恶性瘤至关重要.
- 这一案例强调了考虑在非典型症状和正常PSA的患者中除前列腺癌之外的差异诊断的重要性.
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