结节性脊柱炎肠道微生物组的变化及其与疾病活动的相关性
Hyemin Jeong1, Hoonhee Seo2, Sukyung Kim2
1Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 14584, Republic of Korea.
Journal of microbiology and biotechnology
|December 21, 2025
概括
性脊柱炎 (AS) 患者表现出改变的肠道细菌,具有较高的蛋白质细菌和较低的有益微生物. 疾病活动与微生物多样性减少和潜在生物标志物Coprobacter增加有关.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物组在免疫系统调节中起着至关重要的作用.
- 在结性脊柱炎 (AS) 中观察到肠道失调和免疫功能障碍.
- 了解AS特定的微生物变化对于识别疾病生物标志物至关重要.
研究的目的:
- 在结性脊髓炎 (AS) 患者中描述独特的肠道微生物特征.
- 为了确定与AS疾病活动相关的微生物生物标志物.
主要方法:
- 来自44名AS患者和50名健康对照 (HC) 的便样本的16S rRNA测序.
- 评估微生物的α和β多样性.
- 微生物丰富度与疾病活性得分的相关性分析 (ASDAS-CRP,BASDAI).
主要成果:
- 与HC相比,AS患者表现出改变的β多样性,蛋白质细菌 (gammaproteobacteria,enterobacterales) 增加,有益的种群 (firmicutes,fecalibacterium) 减少.
- 在AS患者中,高的疾病活性与减少的α多样性有关.
- 这种细菌是Coprobacter spp. 丰富度与BASDAI和ASDAS-CRP分数都有正相关.
结论:
- 脊髓炎患者具有独特的肠道微生物群组成,其特点是蛋白质细菌的扩张和有益细菌的减少.
- 降低AS中的α多样性与较高的疾病活性相关.
- 这种细菌是Coprobacter spp. 显示出作为AS疾病活动预测生物标志物的潜力.
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