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Updated: Jun 3, 2026

Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro
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Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro

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对FDX1的深度突变扫描识别了脂化和cuproptosis的关键结构决定因素

Jeffrey C Hsiao1, Douglas M Warui2,3, Jason J Kwon4

  • 1Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Nature communications
|December 21, 2025
PubMed
概括

费雷多克辛1 (FDX1) 对于亡至关重要,这是一个细胞死亡途径,涉及铜过载. 在FDX1上的特定残留物.

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相关概念视频

Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...