一种基于毛孔性指数的骨声学建模的新方法
Dechen Kong1, Tao Zhang2,3,4, Guozheng Hou1
1Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
Scientific reports
|December 21, 2025
概括
使用MRI扫描的新孔径指数 (PI) 方法为跨超声波刺激 (TUS) 治疗计划提供了无辐射的替代方案. 这种方法准确地模拟了头骨声学,匹配了对基本震和阿尔茨海默病治疗的CT扫描结果.
科学领域:
- 神经调节是一种神经调节.
- 医疗成像医学成像
- 声学建模 声学建模
背景情况:
- 超超声刺激 (TUS) 是一种经过验证的神经调节技术.
- 阶段式阵列超声波可实现非侵入性皮质和深度大脑刺激.
- 目前的TUS规划使用CT扫描,冒着辐射暴露和注册错误的风险.
研究的目的:
- 引入一个孔径指数 (PI) 方法,使用UTE-MR图像作为CT的替代方案,用于TUS头骨声学建模.
- 为了验证PI方法在预测头骨多孔性和模拟超声波焦点分布方面的准确性.
- 为了消除与基于CT的TUS规划相关的辐射暴露和注册错误.
主要方法:
- 从超短回声时间 (UTE) 的MRI图像开发出一个孔径指数 (PI).
- 利用K-Wave开源平台进行声学模拟.
- 使用峰值强度,目标强度,子系数和皮尔森相关性量化焦点特征,比较基于PI和基于CT的模拟.
主要成果:
- 基于PI的声学模型显示了与CT衍生模型相比的性能.
- 峰值焦点强度的偏差小于5%.
- 空间压力分布模式实现了大于0.82的子系数,没有显著的统计差异 (p > 0.05).
结论:
- 孔径指数 (PI) 方法准确预测头骨孔径,并模拟TUS的声压分布.
- 基于PI的建模是一种可行的CT替代方案,可以减少患者的辐射暴露和注册错误.
- 这一进步支持对神经疾病的更安全,更准确的TUS治疗计划.
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