评估剂量学放射性工具的一致性:一个多软件的比较研究
Andrea Bettinelli1, Francesca Marturano2, Giovanni Pirrone3
1Medical Physics Department, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Medical physics
|December 21, 2025
概括
剂量学 (放射治疗剂量分布) 的软件差异可能会阻碍可重现性. 这项研究发现,虽然特征提取工具存在一些变化,但正确的配置确保了剂量模型的良好一致性.
科学领域:
- 放射学和医学成像技术
- 辐射瘤学和剂量测量
- 计算生物学和生物信息学
背景情况:
- 放射学从医疗图像中提取定量特征,以支持决策.
- 剂量学将放射学应用于放射治疗剂量分布,以将空间模式与结果联系起来.
- 功能提取中的软件变异性对dosiomics的可复制性和临床采用构成了挑战.
研究的目的:
- 在 dosiomics 中全面评估软件协议和功能可重现性.
- 评估预处理 (插值,离散) 和特征提取配置对剂量学模型的影响.
- 分析兴趣区域 (ROI) 形态特征对特征可重现性的影响.
主要方法:
- 评价了七个dosiomic特征提取工具 (五个开源,两个专有).
- 使用图像生物标记标准化倡议 (IBSI) 数字幻影进行合规评估.
- 从IMRT剂量分布和ROI中提取了剂量特征,分析了预处理和ROI形态的影响.
主要成果:
- 四个工具显示>94%的IBSI合规性;其他工具由于不可计算的特征而具有较低的合规性.
- 在同位素剂量数据集中观察到很高的一致性,但在异位素数据和特定程序插值时,差异显著增加.
- 固定 bin 尺寸分类和某些特征家族/聚合方法的变化影响了一致性和可变性.
结论:
- 当正确配置时,dosiomic工具表现出良好的整体一致性,变化与特定特征和预处理选择相关.
- 尽管在重新采样和离散中存在差异,但对剂量学特征可重现性的整体影响很小.
- 标准化的实施和仔细的配置是放射治疗中可靠的剂量分析的关键.
相关概念视频
01:26Pharmacokinetic Models: Comparison and Selection Criterion
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
01:30Measurement of Bioavailability: Pharmacokinetic Methods
Pharmacokinetics is a vital branch of pharmacology that examines how drugs are absorbed, distributed, metabolized, and excreted by the body. Two key methodologies in pharmacokinetics are plasma drug concentration studies and urinary drug excretion analyses, both of which provide critical insights into a drug's therapeutic efficacy and bioavailability.Plasma Drug Concentration-Time StudiesPlasma drug concentration-time studies involve analyzing blood samples at specific intervals to quantify...
01:20Measurement of Bioavailability: Pharmacodynamic Methods
Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.
01:16Bioequivalence Data: Statistical Interpretation
The statistical interpretation of bioequivalence data is a significant aspect of pharmaceutical research. Bioequivalence refers to the absence of any significant difference in the rate and extent to which the active ingredient in pharmaceutical products becomes available at the site of drug action when administered at the same molar dose under similar conditions. This helps determine if different drug products have similar absorption rates, ensuring their interchangeability.Statistical...
01:14Drug Dissolution: Requirements and Profile Comparison
The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...