在癌症免疫疗法治疗期间,用甲基酸盐控制疲劳和身体活动
Sriram Yennurajalingam1, Bryan Fellman2, Lisa Williams1
1Department of Palliative Care, Rehabilitation, and Integrative Medicine, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Palliative & supportive care
|December 21, 2025
概括
甲基酸 (MP) 与体力活动 (PA) 结合,在晚期癌症患者中显著改善了与癌症相关的疲劳 (CRF). 这种组合疗法为免疫治疗患者的严重疲劳管理提供了一个有希望的新途径.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 运动生理学 运动生理学
背景情况:
- 与癌症相关的疲劳 (CRF) 是在接受免疫治疗的晚期癌症患者中普遍存在的衰弱症状.
- 对于严重的CRF,有效的治疗选择有限,影响患者的生活质量.
研究的目的:
- 调查甲基酸盐 (MP) 与标准化体力活动 (PA) 结合在缓解CRF时的疗效.
- 探索MP+PA对各种维度的疲劳和心理痛苦的影响.
主要方法:
- 一项试点随机对照试验,涉及具有显著CRF的晚期癌症患者,接受抗PD1免疫疗法.
- 参与者被随机分配,接受MP + PA或安慰剂 + PA14天.
- 主要结局是癌症疾病治疗功能评估 - 疲劳 (FACIT-F) 评分的变化;次要结局包括其他疲劳和情绪评估.
主要成果:
- 无论是MP + PA还是安慰剂 + PA组,FACIT-F得分均显著改善.
- 在MP + PA手臂中,在PROMIS-疲劳,MFSI-SF (全球) 和HADS-抑郁症得分方面表现出了额外的显著改善.
- 两组之间没有观察到不良事件的显著差异.
结论:
- 甲基酸与体育活动相结合显示出作为治疗癌症相关疲劳的有效干预措施的潜力.
- MP + PA组合可能提供更广泛的好处,包括改善疲劳尺寸和抑郁症.
- 需要进一步的研究,以在更大的比较研究中证实这些发现.
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