菲兰达 (Phyllanthus emblica L.) 提取物的生物可获得性及其作为一种功能性食品的潜力,以保护其免受炎症性肠病的侵害
Yining Hao1, Shishuai Yu2, Bo Peng2
1Yunnan Characteristic Plant Extraction Laboratory, Kunming, China.
Journal of the science of food and agriculture
|December 21, 2025
概括
菲兰特 (Phyllanthus emblica) 提取物具有很高的消化稳定性和抗氧化能力. 它有效地减少炎症并保护肠道,支持其用于肠道健康和炎症性肠病预防.
科学领域:
- 药理学和植物化学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 普兰 (Phyllanthus emblica L. (PE)) 是一种以抗氧化和抗炎性质而闻名的药用植物.
- 需要澄清PE多的消化命运和肠道保护作用.
- 这项研究研究了PE提取物的体外消化,抗氧化能力和抗结肠炎潜力.
研究的目的:
- 评估Phyllanthus emblica提取物中的多的消化稳定性和生物可访问性.
- 为了评估PE在模拟消化过程中的抗氧化活性.
- 为了确定PE在斑马鱼发炎性肠病模型中的疗效.
主要方法:
- 在体外消化模型模拟口腔,胃和肠道阶段.
- 液体染色学与四极飞行时间质谱学 (LC-Q-TOF-MS) 结合,用于多的识别.
- 斑马鱼模型的三二硫酸 (TNBS) 诱导的炎症性肠病.
- 亲炎性细胞因子的基因表达分析.
主要成果:
- PE具有较高的全生物可访问性 (92.03%) 和部分类生物可访问性 (42.69%).
- 鉴定出3-O-基酸和酸是主要的,稳定的.
- PE保持了强大的抗氧化能力,并通过减少炎症和恢复粘膜完整性,显著改善斑马鱼TNBS诱导的大肠炎.
- 通过剂量依赖的方式观察到促炎性细胞因子 (tnf-α,il-1β,il-6) 的下调.
结论:
- 菲兰特 (Phyllanthus emblica) 提取物显示出显著的消化稳定性和多的生物可访问性.
- 提取物保留了强大的抗氧化和抗炎活性,具有显著的粘膜保护作用.
- 作为一种功能性食品成分,PE有望促进肠道健康和预防炎症性肠道疾病.
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