化学疗法诱导的外围神经病变的评估工具:临床医生,患者报告和客观措施的叙述性审查
Kaitlin Chen1, Eric Antonen2,3, Michelle B Nadler4
1Medical Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
JNCI cancer spectrum
|December 22, 2025
概括
本综述总结了化疗诱导的外围神经病变 (CIPN) 评估工具. 许多工具在CIPN群体中缺乏验证和临床重要差异最小值 (MCID),需要进一步研究以获得最佳的临床选择.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 临床评估 临床评估
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 是一种影响运动,感官和自主功能的普遍不良影响.
- 准确的CIPN评估对于治疗管理和治疗后的生存率至关重要,这显著影响了生活质量.
- 目前的评估方法包括主观 (基于临床医生,患者报告的结果指标 [PROMs]) 和客观指标.
研究的目的:
- 系统地审查和总结现有的CIPN评估工具.
- 突出这些工具的关键特征,包括可行性,有效性,可靠性和最低临床重要差异 (MCID).
- 促进临床医生和研究人员明智地选择合适的工具.
主要方法:
- 根据叙事评论文章评估尺度 (SANRA) 准则进行了全面的文献搜索.
- 调查人员通过使用预定义的搜索术语,并通过审查系统性审查和关键文章的引用来确定相关论文.
- 从已识别的源文件和附录中进行了数据提取.
主要成果:
- 该审查确定了3个基于临床医生的分级表,20个PROM和8个客观测量工具,用于CIPN.
- 虽然大多数工具已被验证用于一般的神经病变,但只有少数人在CIPN群体内建立了MCID和特定验证.
- 在审查的评估工具的心理测量特性和临床实用性方面存在显著的变化.
结论:
- 对于CIPN评估的工具选择应根据临床医生和研究人员的具体要求进行定制.
- 推的工具应该证明有效性,可靠性和评估多个CIPN领域的能力.
- 进一步的研究对于验证CIPN特定群体的现有工具和建立其MCIDs以改善临床应用至关重要.
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