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听力学和组织病理学评估卡斯特拉尼溶液的耳毒效应

Serdal Celik^1,2, Berina Slipcevic^1,2, Murat Erinc³

¹Department of Otorhinolaryngology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Türkiye.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

|December 22, 2025

概括

卡斯特拉尼溶液通过穿孔的鼓膜进入中耳时会导致听力损失和耳损伤. 这种耳毒性作用需要在这种情况下在使用时非常小心.

科学领域:

耳部毒理学耳部毒理学
审计科学审计科学
组织病理学组织病理学

背景情况:

卡斯特拉尼溶液有效治疗外部耳道疾病,包括真菌感染.
如果溶液通过耳穿孔进入中耳,则存在潜在的耳毒性.

研究的目的:

为了研究卡斯特拉尼溶液的耳毒作用.
为了关联听力学和组织病理学发现.

主要方法:

动物模型注射了卡斯特拉尼溶液,对照溶液或水.
听力大脑干反应 (ABR) 用于听力值评估.
耳组织的组织病理学检查.

主要成果:

与对照组相比,内卡斯特拉尼溶液导致了显著的听力损失.
组织病理学揭示了耳细胞缩和毛细胞退化.

结论:

卡斯特拉尼溶液具有耳毒性.
在患有耳膜穿孔的患者使用卡斯特拉尼溶液时建议谨慎使用.

关键词:

听觉脑干反应的响应卡斯泰拉尼的解决方案组织病理学组织病理学耳部毒性耳部毒性

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