超越显微型大肠炎:对内镜显而易见的原性大肠炎进行临床病理学评估,包括扩散结节型变体
Xia Qian1, Lisha Wang1, Catherine Cheney2
1Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.
内镜明显的质结肠炎 (CC),包括结节性CC (NCC),尽管接受了治疗,但仍可能持续存在. 如果临床和组织学特征与典型的CC相似,则不应排除诊断.
科学领域:
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
- 内镜检查是指内镜检查.
背景情况:
- 质结肠炎 (CC) 的特点是慢性水性腹和加厚的副皮质质层,通常具有正常的内镜发现.
- 包括结节性模式在内的内镜显而易见的CC变异较少被描述.
研究的目的:
- 描述内镜显然变体的质结肠炎,特别是结节性质结肠炎 (NCC).
- 分析正常的临床,内镜和组织学特征与内镜明显的CC变体.
主要方法:
- 对201例原性大肠炎 (CC) 病例的回顾性审查.
- 对内镜检测结果的分类为正常,微妙的异常或结节性CC (NCC).
- 临床特征,药物暴露和组织学分析.
主要成果:
- 在12.9%的CC病例 (16个微妙,10个NCC) 中观察到内镜异常.
- 临床,组织学和治疗特征在各组之间没有显著差异.
- 观察到的趋势包括明显的CC中帕内斯细胞代谢的增加,乳病的更高流行率和在NCC中使用血管激素受体抑制剂.
结论:
- 内镜显现的CC,包括NCC,可以持续存在,并且可能存在明显的相关条件.
- 如果其他特征一致,内镜异常的存在不应阻止诊断CC.
- 内镜检测结果,如结节性,即使在临床缓解后也可能持续存在.
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