尿路转移类型是否会影响女性患者的激进囊切除术后的术后并发症?
Mazyar Zahir1, Farshad Sheybaee Moghadam1, Seyedeh-Sanam Ladi-Seyedian1
1Department of Urology, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
概括
尿路转移类型对女性激进囊切除术后的整体并发症的影响很小. 然而,大陆皮肤转移 (CCD) 在90天内显著增加了生殖尿道并发症的风险.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 手术瘤学手术瘤学
- 重建性手术是一种重建性手术.
背景情况:
- 激进囊切除术 (RC) 是膀癌的标准治疗方法.
- 在RC之后,尿路转移 (UD) 是必要的,以恢复尿路的连续性.
- 选择UD可能会影响女性患者的术后结果.
研究的目的:
- 评估不同尿路转移 (UD) 类型对进行激进囊切除术 (RC) 的女性患者手术后并发症的影响.
- 为了在这个人群中比较状管 (IC),新膀 (NB) 和大陆皮肤转移 (CCD) 的并发症率.
- 在当代队列中确定尿生殖系统 (GU) 并发症的特定风险因素.
主要方法:
- 对女性RC患者数据库 (2003-2024) 的回顾性审查.
- 根据UD类型分类的患者:IC,NB或CCD.
- 在手术后30天和90天的整体和生殖尿道 (GU) 并发症率的比较.
主要成果:
- 在所有UD类型中,30天和90天的整体并发症率是可比的 (p > 0.195).
- 生殖尿路 (GU) 并发症在90天后的CCD组相比IC和NB中明显更频繁 (p < 0.001).
- 在当代的子队列中,CCD仍然独立地与90天GU并发症的更高几率相关 (OR:3.79,p=0.011).
结论:
- 尿路转移类型对女性患者在RC后的整体术后并发症的影响有限.
- 大陆皮肤转移 (CCD) 与在RC后90天内发生生殖尿道并发症的风险明显增加有关.
- 这一发现有助于为女性RC患者选择最佳的UD策略,以尽量减少GU特异性发病率.
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