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Updated: Jan 8, 2026

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与癌症相关的DAXX突变揭示了ATRX定位在ALT抑制中的关键作用

Sarah F Clatterbuck Soper1, Robert L Walker1, Marbin A Pineda1

  • 1Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Molecular and cellular biology
|December 22, 2025
PubMed
概括

DAXX蛋白对于通过局部化ATRX. 抑制替代端粒延长 (ALT) 是至关重要的. 与疾病相关的DAXX突变损害了这一功能,可能导致癌症中的ALT.

关键词:
在ATRX的本地化.端粒的替代延长 (ALT)在DAXX中发生的突变.组织素 H3.3 陪伴者复合体

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