酸增强化对 Streptococcus mutans 的抗菌作用:对空控制的协同方法
Ravichellam Sangavi1, Nambiraman Malligarjunan1, Shunmugiah Karutha Pandian1
1Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, India.
酸 (RA) 与化 (NaF) 结合,显示出对口腔细菌的强有力的协同作用. 这种组合增强了NaF.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 牙科科学 牙科科学
背景情况:
- 牙损是由口腔微生物组失生症引起的,其中有Streptococcus mutans过度生长.
- 化 (NaF) 是一种标准的虫预防药物,但在高风险患者和耐药菌株患者中存在局限性.
- 需要新的策略来增强皮预防和打击化物耐药性.
研究的目的:
- 研究NaF与酸 (RA) 结合的协同抗菌作用.
- 评估该组合对Streptococcus mutans及其生物膜的疗效.
- 阐明协同作用相互作用的基本机制.
主要方法:
- 检查板和时间杀戮测试被用于确定组合最小抑制度 (CMIC).
- 对焦显微镜评估生物膜破坏.
- 机械学研究分析了反应性氧物种 (ROS) 生成,膜完整性和毒性因子抑制 (酸性生成,酸性).
主要成果:
- RA和NaF对S. mutans表现出强烈的协同作用,其CMIC为64 + 128μg/mL.
- 该组合在120分钟内根除了S. mutans,并将生物膜生物质减少了82%.
- 通过诱导ROS和膜干扰,RA增强了NaF的吸收,抑制了S. mutans毒性因子~76%和~71%,并且没有引起耐药性.
结论:
- RA 通过包括氧化应激,膜破坏和代谢抑制在内的多目标机制强化 NaF 的抗原活性.
- RA-NaF组合是一种有希望的,化物效率高的策略,用于预防和治疗牙损伤.
- 这种协同方法为高风险个体和耐菌株提供了增强的治疗潜力.
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