持续的有机污染物暴露与DNA甲基化衰老生物标志物之间的关联:来自全国代表性研究的见解
Ya-Qian Xu1,2, Yulu Gong1,2,3, Chongyu Ding1
1School of Global Health, Chinese Centre for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
International journal of environmental health research
|December 22, 2025
概括
持久性有机污染物 (POPs) 对表观遗传衰老的影响不同. 一些多双 (PCB) 会减缓衰老,而 furan 和农药则会加速衰老,特别是在女性和老年人身上.
科学领域:
- 环境健康 环境健康
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 毒理学 毒理学 毒理学
背景情况:
- 持久性有机污染物 (POP) 是广泛存在的环境污染物.
- 负面的健康结果与POPs有关,但它们对表观遗传衰老的影响尚未完全理解.
研究的目的:
- 研究血清POP度与基于DNA甲基化 (DNAm) 的衰老加速之间的关联.
- 探索 POPs如何影响美国成年人的表观遗传衰老轨迹.
主要方法:
- 血清POPs (PCB,二氧化物, furan,OCP) 在NHANES 1999-2002测量了815名美国成年人 (≥50岁).
- 用十二个基于DNAm的表观遗传时钟估计了表观遗传年龄加速.
- 统计分析检查了关联,包括性别分层和特定年龄的模式.
主要成果:
- 观察到双向关联:大多数PCB与表观遗传年龄加速相反相关,而一些 furan 和 OCP 则显示出积极的关联.
- 按性别分层的分析表明,OCP与女性死亡率钟之间的积极关联更强.
- 年龄特定的模式揭示了某些PCB与老年人的表观遗传年龄加速之间的放大反向关联.
结论:
- 暴露在POP中以一种化合物特定的方式差异调节表观遗传衰老.
- 性别和年龄改变了POP和表观遗传衰老之间的关系.
- 调查结果强调需要针对POPs进行量身定制的风险评估,考虑到脆弱人群.
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