精准医学时代的辐射疗法:一个叙事性回顾
Yingqi Gu1, Yujin Peng2, Xiaofang Li3
1Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Chinese clinical oncology
|December 22, 2025
概括
放射治疗 (RT) 通过诱导免疫细胞死亡 (ICD) 和激活cGAS/STING通路来调节瘤免疫微环境 (TIME). 符合RT优化抗瘤效果,同时最大限度地降低毒性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 辐射瘤学 辐射瘤学
背景情况:
- 放射治疗 (RT) 诱导DNA损伤,并调节瘤免疫微环境 (TIME).
- RT可以促进促炎和免疫抑制的免疫细胞透.
- 了解RT的免疫调节作用对于优化癌症治疗至关重要.
研究的目的:
- 审查放射治疗的主要免疫调节作用.
- 分析RT对瘤免疫微环境的免疫刺激作用.
- 探索RT参数如何影响生物和免疫反应.
主要方法:
- 在PubMed上搜索过去十年的文章.
- 关键词包括辐射疗法,合规放射治疗,免疫细胞死亡,cGAS/STING通路,TIME和低剂量放射治疗.
- 对现有文献进行全面分析.
主要成果:
- RT诱导免疫细胞死亡 (ICD) 并激活循环GMP-AMP合成酶 (cGAS) /干扰素基因刺激器 (STING) 途径.
- RT调节瘤微环境 (TME) 中的免疫细胞群,根据剂量和分成有不同的效果.
- 合规RT可实现精确的剂量递送,不影响健康组织.
结论:
- 放射治疗通过ICD和cGAS/STING通路激活产生抗瘤作用,重塑了TIME.
- RT的免疫调节作用取决于辐射剂量和分量.
- 合规RT通过精确瘤向和减少正常组织毒性来提高治疗结果.
相关概念视频
Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Radiation: Applications
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
The average...


