老年人的COVID后认知障碍:症状严重程度和心血管并发症的影响
Reza Amini1, Idorenyin Udoh1, Jahanvi Patel1
1Department of Public Health and Health Sciences, College of Health Sciences, University of Michigan-Flint, Flint, MI, USA.
概括
COVID-19 症状严重程度会影响老年人的执行功能. 中度至严重的症状,特别是心脏病或中风,显著增加认知障碍的风险,强调需要综合查.
科学领域:
- 老年学是指老年学的学科.
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19可能会影响认知功能,特别是在老年人中.
- 执行功能和记忆对于老龄化人口的日常生活至关重要.
- COVID-19的长期认知后果需要进一步调查.
研究的目的:
- 调查老年人中COVID-19症状严重程度和认知功能 (记忆和执行功能) 之间的关联.
- 为了确定先前存在的心血管疾病是否会改变这种关系.
- 为COVID-19后认知健康提供临床查和干预策略的信息.
主要方法:
- 利用了来自国家健康和衰老趋势研究的数据.
- 使用即时和延迟单词回忆测试和时钟绘图测试评估认知功能.
- 分析了COVID-19症状严重程度 (没有,轻度,中度至重度) 与认知表现之间的关联,使用混合效应的顺序逻辑回归,控制共变量.
主要成果:
- 中度至重度的COVID-19症状与执行功能不良的可能性增加了1.5倍.
- 心脏病加剧了这种风险,使执行功能受损的几率增加了近两倍 (OR = 1.942).
- 轻微的COVID-19症状与中风病史相结合,使执行功能受损的风险增加了十三倍以上.
结论:
- 在老年人中,COVID-19症状严重程度和执行功能缺陷之间存在显著的关联.
- 诸如心脏病和中风等心血管疾病加剧了COVID-19相关的认知障碍.
- 在COVID-19后的认知和心血管查对于老年人来说至关重要,以防止长期的认知衰退.
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