人类免疫缺陷病毒 (HIV) - 结核联合感染中早期死亡率的预测因素
Melike Nur Ozcelik1, Esra Zerdali2, Inci Yilmaz Nakir2
1Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Namik Kemal University, Tekirdag, Türkiye.
International journal of STD & AIDS
|December 22, 2025
概括
艾滋病毒 (PLWH) 和结核病 (TB) 联合感染的人群的高早期死亡率与严重的免疫抑制和血液细胞计数异常有关. 早期发现和监测艾滋病毒对于减少这些患者的死亡率至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 仍然是艾滋病毒感染者 (PLWH) 的重要机会性感染.
- 了解结核病/艾滋病毒联合感染的特征和死亡率预测因素对于改善患者的治疗结果至关重要.
研究的目的:
- 为了识别与结核病同时感染的艾滋病毒感染者 (PLWH).
- 探索他们的人口和临床特征.
- 确定结核病诊断后6个月内早期死亡率的预测因素.
主要方法:
- 在土耳其进行了一项横截面研究,审查了2004年至2023年期间诊断出结核病的PLWH的数据.
- 进行了统计分析,包括ROC分析,以确定早期死亡率的预测因素.
主要成果:
- 在1541名PLWH中,62人 (4%) 患有结核病;23人 (37%) 在6个月内死亡.
- 早期死亡预测因素包括淋巴缺血症,CD4+ T淋巴细胞计数≤50细胞/mm3,贫血和血栓缺血症 (<150,000/mm3).
- 发烧,厌食症,减肥和精神状况改变等临床症状也是显著的预测因素.
结论:
- 在PLWH/TB联合感染中,高早期死亡率与先进的免疫抑制和血液学异常有关.
- CD4+ T 淋巴细胞数 ≤50 细胞/mm3 和血小板数 <150,000/mm3 是早期死亡的重要预测因素.
- 早期发现艾滋病毒和密切的临床监测对于降低这一群体的死亡率至关重要.
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