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在母亲高脂肪饮食影响下,胚胎心脏发育中的NOTCH1和UPR信号

Yupeng Shi1,2, Bingyu Li2,3, Qingyun Shi1,2

  • 1Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Frontiers in medicine
|December 22, 2025
PubMed
概括

在怀孕前和怀孕期间,母亲的高脂肪饮食 (HFD) 通过激活未折叠蛋白质响应 (UPR) 途径来破坏胚胎心脏发育. 这导致NOTCH1表达的抑制和亡的增加,突显出需要均衡的孕产妇饮食.

关键词:
在NOTCH1中,健康和疾病的发育起源.需要伊诺西的蛋白1α (IRE1α)母亲的高脂肪饮食 (HFD)展开的蛋白质反应 (UPR)

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