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基于生理学的药理动力学建模和模拟,用于儿科中使用 levetiracetam 的初始剂量优化

Julia Macente1, Rodolfo Hernandes Bonan2, Edilainy Rizzieri Caleffi-Marchesini3

  • 1Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

Frontiers in pharmacology
|December 22, 2025
PubMed
概括

基于生理学的药理动力学 (PBPK) 建模和多变量线性回归 (MLR) 优化了儿童的 levetiracetam (LEV) 剂量. 这种方法有助于选择初始LEV剂量,改善治疗结果,并为儿科患者提供个性化的治疗.

关键词:
在 PBPK 建模中使用 PBPK 模型.剂量优化剂量优化是一种.莱维泰拉塞坦 ( levetiracetam) 的使用情况儿科人口中的儿科人口.

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