在大脑病理中的内皮谷氨酸受体
Sergey V Pirozhkov1, Marina N Vukolova1, Varvara V Bulgakova2
1Department of Pathological physiology, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Frontiers in pharmacology
|December 22, 2025
概括
内皮质谷氨酸受体调节大脑的血液流动和屏障完整性. 调节这些受体为神经系统疾病 (如阿尔茨海默氏症,中风和创伤性脑损伤) 提供了一个有前途的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 血管生物学 血管生物学
- 细胞信号传递 细胞信号传递
背景情况:
- 大脑内皮对于调节微循环至关重要,包括血液流动,透性和结构完整性.
- 内皮细胞 (ECs) 表达谷氨酸受体,这些受体介导影响血管过程的信号转导通路.
- 这些通路的失调与神经疾病有关,突出显示了内皮在大脑平衡中的积极作用.
研究的目的:
- 审查内皮质谷氨酸受体在脑病理学中的作用.
- 探索这些受体如何影响内皮膜透性和神经血管合.
- 讨论对神经系统疾病调节内皮质谷氨酸受体的治疗潜力.
主要方法:
- 文献综述专注于内皮质谷氨酸受体和大脑病理学.
- 在EC中由谷氨酸受体激活触发的信号级联的分析.
- 检查证据,将内皮功能障碍与神经系统疾病联系起来.
主要成果:
- 谷氨酸受体的激活,特别是N-甲基-D-酸盐受体 (NMDARs) 和mGluR1,可以增加内皮通透性,并导致血脑屏障的破坏.
- 内皮功能障碍会损害神经血管合,导致氧气和营养供应不足,并加剧神经元损伤.
- 激活的EC释放出促炎媒介体,吸引白细胞并维持神经炎症,这在创伤性脑损伤等条件下至关重要.
结论:
- 内皮质谷氨酸受体是维持大脑平衡和调节血管功能的关键参与者.
- 向内皮质谷氨酸受体为神经退行性疾病,中风和创伤性脑损伤提供了一个有前途的治疗途径.
- 这些受体的调节可以防止血脑屏障的破坏,并减轻神经炎症和神经元损伤.
关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.血脑屏障是什么意思大脑微血管内皮细胞内皮细胞葡萄糖酸盐受体的受体缺血性脑损伤是一种脑损伤.多发性硬化症多发性硬化症神经炎症是一种神经炎症.系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.更多相关视频
08:27Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
Published on: March 11, 2020
6.5K
07:11Examination of Anatomical Features of Retinal Ganglion Cells Under N-methyl-D-aspartic Acid (NMDA)-induced Excitotoxicity
Published on: September 19, 2025
1.0K
相关概念视频
01:30Ligand-Gated Ion Channel Receptor: Gating Mechanism
3.7K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
3.7K
01:14Antiepileptic Drugs: Glutamate Antagonists
857
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
857
01:19Ligand-gated Ion Channels
13.9K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
13.9K