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一个新兴的血统7PRRSV-2 (Prime Pac-Like) 菌株在中国的遗传和致病特征

Yuan Yang^1,2,3, Haoyu Chen^1,2,3, Feimin Xie¹

¹College of Life Sciences, Longyan University, Longyan, 364012, China, lyun.edu.cn.

Transboundary and emerging diseases

|December 22, 2025

概括

一种新的7 (L7) 猪生殖和呼吸系统综合征病毒 (PRRSV) 菌株,FJZHK-2025,在中国被发现. 这种致病菌株是重组的结果,并导致小猪的重大疾病.

科学领域:

兽医病毒学兽医病毒学
分子流行病学分子流行病学
动物病理学动物病理学

背景情况:

猪生殖和呼吸系统综合征病毒 (PRRSV) 对全球猪业构成重大威胁.
类似NADC30 (系谱1.8) 的PRRSV的出现加速了病毒的进化和经济损失.
了解新型PRRSV菌株对于疾病控制至关重要.

研究的目的:

在中国流传的新型PRRSV菌株的隔离和鉴定.
调查新菌株的遗传起源和遗传学关系.
评估小猪中新型PRRSV菌株的致病性.

主要方法:

隔离和PRRSV菌株FJZHK-2025的全长基因组测序.
用已确立的PRRSV序列进行遗传学分析和重组检测.
与已知的PRRSV菌株和疫苗菌株进行比较基因组分析.
在小猪中进行动物挑战实验,以评估病原性和临床症状.

主要成果:

一种新型的第7系 (L7/Prime Pac-like) PRRSV菌株FJZHK-2025在中国被分离出来.
FJZHK-2025与L7PRRSV菌株具有高核酸同质性,并且在NSP2中含有独特的36氨基酸插入,类似于Prime Pac疫苗.
遗传学和重组分析表明,FJZHK-2025起源于L7和Lineage 1.8 (类似NADC30) 的PRRSV-2菌株之间的跨血统重组.
感染FJZHK-2025导致持续发烧,轻度至中度的临床症状,以及小猪的肺部病变,证实了其致病性.

结论:

新型L7PRRSV菌株FJZHK-2025,由重组产生,在小猪中具有致病性.
这一发现凸显了PRRSV在中国的动态演变.
迫切需要有效的战略来控制L7PRRSV在中国猪群中的传播.

关键词:

类似于NADC30的NADC30 总理像Pac一样的Pac.病原性是一种病原性.猪生殖和呼吸系统综合征病毒 (PRRSV)再组合的复合方式.

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