中央和外围血清素在肝脏生理学和疾病中的作用
Arnauld Belmer1, Carmelo Luci1, Philippe Gual1
1Université Côte D'Azur, INSERM, U1065, C3M, Nice, France.
Theranostics
|December 22, 2025
概括
血清素 (5-HT) 通过调节新陈代谢和炎症,在肝脏健康方面发挥着关键作用. 了解其复杂的作用为与代谢功能障碍相关的脂肪性肝病 (MASLD) 和与酒精相关的肝病 (ALD) 提供了新的治疗策略.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 神经内分泌学神经内分泌学
- 代谢性疾病研究研究
背景情况:
- 脂肪性肝病,包括MASLD和ALD,是全球重要的健康问题,导致严重的肝病和死亡率.
- 目前对这些疾病的治疗方法有限,这突显了对新型治疗方法的需求.
- 人们越来越认识到自主神经系统在肝功能和疾病发病过程中的作用.
研究的目的:
- 探索血清素 (5-基三胺,5-HT) 信号在代谢控制,肥胖和慢性肝病中的多方面的作用.
- 检查5-HT与自主神经系统,代谢荷尔蒙和肝脏疾病中的肠肝脑轴的相互作用.
- 讨论5-HT的性作用作为MASLD,ALD和肝细胞癌 (HCC) 的治疗途径的潜力.
主要方法:
- 综合性文献综述,重点关注血清素的信号通路和受体亚型.
- 对5-HT对肝脏代谢,炎症,纤维生成和肝脏再生的影响的分析.
- 整合了关于中央和外围5-HT通路及其对肝病的影响的发现.
主要成果:
- 血清素 (5-HT) 是肝脏葡萄糖和脂质代谢,免疫反应和纤维生成的关键调节剂.
- 5-HT通过联合的中央和外周路径调节肝脏生理和疾病进展.
- 肠-肝-脑轴显著影响5-HT在代谢和肝脏健康中的作用.
结论:
- 血清激素 (5-HT) 信号传递是代谢功能障碍相关的脂肪性肝病 (MASLD) 和酒精相关的肝病 (ALD) 病原发生的关键调解者.
- 针对5-HT通路,考虑到其双重起源和多种受体相互作用,为治疗MASLD,ALD和HCC提供了有前途的治疗机会.
- 对神经内分泌免疫系统中5-HT复杂相互作用的进一步研究是有效的临床转换的必要条件.
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