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绿色合成的Ag纳米颗粒作为有希望的抗菌和抗瘤剂:在体外研究中

Shadi Mansour Hosseini¹, Atena Soleimani¹, Sepideh Khaleghi¹

¹Department of Biotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Indian journal of microbiology

|December 22, 2025

概括

使用菜合成的绿色银纳米粒子 (Ag NPs) 显示出强大的抗微生物和抗癌作用. 这些生物相容的AgNP有效地抑制了乳腺癌细胞和细菌,证明了它们的治疗潜力.

科学领域:

纳米技术纳米技术
生物技术是生物技术.
材料科学材料科学材料科学

背景情况:

新出现的健康威胁需要新的治疗策略.
生物相容纳米材料为疾病治疗提供了有前途的途径.
菜 (菜) 是绿色合成的可持续来源.

研究的目的:

为了绿色合成银纳米粒子 (Ag NPs),使用Spinacia oleracea.
评估AgNP对乳腺癌细胞 (MCF-7,MDA-MB-231) 和细菌 (S. aureus,S. epidermidis,P. aeruginosa) 的疗效.
描述合成的AgNP并评估它们的生物活动.

主要方法:

使用Spinacia oleracea提取物进行Ag NP的绿色合成.
使用FT-IR,XRD,DLS,TEM和SEM进行Ag NP的表征.
抗微生物测定 (MIC,MBC). 抗微生物测定 (MIC,MBC). 抗微生物测定 (MIC,MBC). 抗微生物测定 (MIC,MBC). 抗微生物测试 (MIC,MBC). 抗微生物测试 (MIC,MBC). 抗微生物测试 (MIC,MBC). 抗微生物测试 (MIC,MBC). 抗微生物测试 (MIC,MBC). 抗微生物测试 (MIC,MBC). 抗微生物测试 (MIC,MBC).
抗癌检测包括细胞活力 (MTT),基因表达 (qRT-PCR),细胞周期停止和细胞亡.

主要成果:

生物合成的AgNP表现出纳米尺寸 (10-25nm) 和球形形态.
有效抑制细菌生长,最小抑制度 (MIC) 值在20-35nM之间.
显著抑制乳腺癌细胞活力,诱导细胞亡和细胞循环停止.
调节关键的癌症相关基因,包括BRCA1,BRCA2,Caspase9,Bcl2,Beclin1和ATG.

结论:

香中介的AgNP是生物相容的,并具有显著的抗微生物和抗癌特性.
这项研究证实了绿色合成的AgNP作为治疗癌症和细菌感染的治疗剂的潜力.
这种方法为开发新型纳米药物提供了一种安全和可持续的方法.

关键词:

在Ag纳米粒子中.抗菌能力抗菌能力它具有抗瘤能力.绿色合成是一种绿色合成.

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