在耐火性Helicobacter pylori感染中出现阿莫西西林耐药性
Cheng-Yu Lin1,2, Chia-Jung Kuo1,2,3, Chih-Ho Lai4
1Department of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Therapeutic advances in gastroenterology
|December 22, 2025
概括
耐治疗的Helicobacter pylori感染对常见的抗生素具有很高的耐药性. 观察到阿莫西西林耐药性的显著增加,需要修订治疗策略.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- Helicobacter pylori 的抗生素耐药性是一个重大的全球卫生挑战.
- 治疗失败率正在增加,需要了解不断演变的耐药性模式.
研究的目的:
- 调查台湾治疗耐药H.pylori感染患者抗菌素耐药性的时间趋势.
- 识别具有耐药性增加的特定抗生素,以告知临床实践.
主要方法:
- 对至少有两次之前H. pylori根除失败的成年患者的回顾性分析.
- 使用Epsilometer测试对H. pylori分离物的抗菌敏感性测试.
- 从2018年到2024年,对阻力模式进行时间趋势分析.
主要成果:
- 对克拉里胺 (89.9%),西普罗素 (87.2%),莱沃素 (86.2%) 和美特罗尼达 (71.6%) 观察到高耐药率.
- 检测到阿莫西西林耐药性的统计显著增加 (每年OR,1.60;p < 0.001).
- 对四环素的耐药性仍然相对较低 (15.6%).
结论:
- 耐火性H. pylori感染对克拉里素,诺基诺和美特罗尼达具有持续的高耐药性.
- 令人担忧的阿莫西西林耐药性急剧增加凸显了更新经验治疗指南的必要性.
- 加强抗微生物药物管理对于具有高耐药率的地区至关重要.
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