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Transdermal Drug Delivery Systems

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...

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多面微针贴片:一站式解决方案,用于对抗多种类型的伤口感染.

Hui Xin^1,2,3, Yinghua Xu⁴, Lingling Pan^1,2,3

¹Intensive Care Unit, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518031, People's Republic of China.

Biomaterials research

|December 22, 2025

概括

一个新的微针贴片提供了动态伤口监测和治疗. 它通过pH值变化对感染进行视觉信号,并释放治疗药物,加速复杂和糖尿病伤口的愈合.

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科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
伤口愈合治愈伤口愈合

背景情况:

细菌感染的伤口是一个全球性的健康挑战,由多微生物感染和改变的微环境而复杂化.
目前的治疗方法在复杂的伤口场景中难以实时监测和有针对性的干预.

研究的目的:

开发一种对微环境敏感的微针 (MN) 贴片,用于动态诊断和对细菌感染的伤口进行分级干预.
将视觉pH预警系统与酶触发的外体细胞输送和多疗效有效载荷相结合.

主要方法:

一个MN贴片的制造,其中包括一个布罗莫提摩尔蓝色pH指标,凝甲基/外体基因组用于酶触发的释放,以及化酸纳米管,抗菌和沙尔维亚诺酸B.
在体外评估抗菌活性对MRSA/IPRPA,生物膜抑制和破坏.
在急性和慢性感染伤口模型中的体内评估,包括糖尿病,评估愈合率,炎症标志物和血管生成.

主要成果:

在体外超过95%的细菌清除和90%的生物膜抑制/破坏.
在急性和慢性伤口中,MNs在8小时内提供了视觉pH值变化.
与对照组相比,在10天内加速急性伤口愈合,糖尿病愈合改善9.20%,显著减少炎症和促进血管生成.

结论:

开发的MN贴片有效地将实时诊断 (pH监测) 与分级治疗干预相结合.
该平台展示了促进复杂和慢性感染伤口,包括糖尿病的管理的重大潜力.
动态预警级干预策略为个性化和高效的伤口护理提供了一个有希望的方法.