患者内分泌并发症 β-thalassemia主要接受铁治疗的患者
Ola M Al-Sanabra1, Manal A Abbas2,3, Abeer A Hazàa4
1Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Al-Salt, Jordan.
Therapeutic advances in endocrinology and metabolism
|December 22, 2025
概括
内分泌功能障碍在β-thalassemia主要患者中普遍存在,尽管铁化疗法,但影响甲状腺,葡萄糖和骨健康. 定期内分泌监测对于这些患者的早期检测和治疗至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 由于慢性输血导致的铁过载,β-thalassemia主要患者面临着重大的健康挑战.
- 这种铁过载经常导致内分泌功能障碍,影响生长,甲状腺功能,葡萄糖代谢和骨健康.
- 这些并发症会对患者的生活质量和长期预后产生负面影响.
研究的目的:
- 为了确定接受铁治疗的β-thalassemia主要患者内分泌功能障碍的患病率和模式.
- 调查内分泌异常与铁过载标志物之间的关系.
- 评估切除术和化疗法的对内分泌结果的影响.
主要方法:
- 一项病例对照研究,比较60名β-thalassemia主要患者与20名健康对照.
- 综合评估荷尔蒙和生化参数,包括铁状况标志物.
- 分析内分泌功能,铁含量和患者特征 (如脊髓切除术状态) 之间的相关性.
主要成果:
- 内分泌问题的高患病率:亚临床甲状腺功能低下症 (15%),血糖代谢异常 (51.7%的HbA1c升高,38.3%的禁食血糖受损) 和-甲状腺-维生素D轴干扰 (11.7%的甲状腺功能低下症,11.7%的甲状腺功能高).
- 与对照人群相比,β-thalassemia患者的维生素D水平显著降低 (71.7%缺乏).
- 铁素 (铁过载标志物) 和FGF21之间的正相关性,与自由甲状腺素的负相关性,表明铁负荷与代谢/甲状腺功能障碍之间的联系.
结论:
- 内分泌干扰在β-thalassemia主要患者中非常普遍,即使使用当前的铁化疗法.
- 早期和常规的内分泌查对于及时诊断和干预至关重要.
- 管理策略应解决与β-thalassemia major相关的多方面的内分泌并发症.
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