解码多细胞系统的分子工具:从机制到医学
Jie P Li1,2, Weiming Guo2,3, Peng Zou2,3
1State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.
National science review
|December 22, 2025
概括
新的分子工具为细胞-细胞通信 (CCC) 提供了前所未有的洞察力,这对健康和疾病至关重要. 这些进展对精准医学有希望,针对细胞相互作用来治疗复杂的疾病.
科学领域:
- 多细胞系统生物学 多细胞系统生物学
- 化学生物学 化学生物学
- 医学科学 医学科学 医学科学
背景情况:
- 细胞-细胞通信 (CCC) 对于生长,分化,免疫监测和组织平衡等生物过程至关重要.
- CCC的失调与包括癌症,自身免疫和神经退行症在内的疾病有关.
- 解读复杂的多细胞相互作用是一个越来越多的科学兴趣的领域.
研究的目的:
- 审查最近在理解细胞间通信方面的跨学科突破.
- 要突出先进的分子工具,使得更深入地了解CCC.
- 讨论这些工具在医学中的翻译潜力.
主要方法:
- 审查研究CCC的分子工具的进步.
- 专注于超高分辨率成像,近距离标记,生物对等化学,合成受体和单细胞空间奥米克等技术.
- 讨论从第380届顺庆论坛的跨学科方法.
主要成果:
- 分子工具为CCC提供了前所未有的空间,分子和功能洞察力.
- 这些工具使我们能够更深入地了解多细胞系统的复杂性.
- 对于免疫瘤学,再生医学和自身免疫性疾病的应用具有显著的翻译潜力.
结论:
- 先进的分子工具正在彻底改变细胞间通信的研究.
- 这些技术为开发针对复杂疾病的向治疗提供了重大前景.
- 倡导未来的精准医学框架,重点是调节细胞-细胞相互作用.
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