Clostridium butyricum MIYAIRI 588 减少结肠直肠腺瘤多的复发:一个随机交叉试验
Jiunn-Wei Wang1,2,3, Wen-Hung Hsu2,3,4, Fang-Jung Yu2,3
1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan.
益生菌Clostridium butyricum MIYAIRI 588 (CBM588) 可能有助于预防高风险患者的结直肠腺瘤复发. 这项研究表明CBM588是预防腺瘤的耐受性良好,非侵入性策略.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 预防医学 预防医学
背景情况:
- 结肠直肠腺瘤多是结肠直肠癌的常见前体.
- 片切除后的复发需要有效的预防策略.
- 高风险患者需要进行干预,以减少腺瘤复发.
研究的目的:
- 评估Clostridium butyricum MIYAIRI 588 (CBM588) 在预防结直肠腺瘤复发方面的疗效.
- 评估CBM588作为具有腺瘤多病史的患者的预防策略.
- 确定CBM588在该患者群体中的安全性和耐受性.
主要方法:
- 进行了一项随机的,单盲的,为期两年的交叉试验.
- 参与者在交替的年份接受CBM588或安慰剂.
- 每年进行监测结肠镜检查,以监测腺瘤复发和多数量.
主要成果:
- 每项协议分析显示,CBM588在第一年显著降低了多胞体数量和腺瘤复发率.
- 对治疗意向的分析表明减少的趋势,尽管在统计学上并不显著.
- CBM588被很好地容忍,没有报告严重的不良事件.
结论:
- CBM588显示出作为一种可行的非侵入性策略来减少结直肠腺瘤复发的潜力.
- 这些发现支持对CBM588进行进一步的研究,以预防结直肠癌.
- 益生菌干预可能为管理腺瘤复发提供一种新的方法.
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