传统中医宪法和老年人认知虚弱:预测模型和睡眠质量调解途径从中国的多中心研究
Mengyuan Qiao1, Sixiang Yang1, Yuping Ma2
1Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Clinical interventions in aging
|December 22, 2025
概括
传统中医宪法 (TCMC) 类型,特别是 Qi 停滞和 Qi 缺乏,是老年人认知虚弱的重要危险因素. 这些TCMC类型可用于风险预测和预防策略.
科学领域:
- 老年学是一门学科.
- 传统中国医药 传统中国医药
- 认知健康 认知健康
背景情况:
- 认知虚弱 (CF) 在老年人群中越来越令人担忧.
- 传统中医宪法 (TCMC) 为了解个人健康倾向提供了一个独特的框架.
- 研究TCMC和CF之间的联系可以揭示预防和管理的新见解.
研究的目的:
- 确定TCMC在识别有认知脆弱风险的老年人中的预测价值.
- 探索TCMC影响认知脆弱的途径.
- 开发和验证基于TCMC的认知脆弱性的预测模型.
主要方法:
- 在中国三个地区招募了905名老年人的队列.
- 参与者接受了多维调查,包括TCMC评估.
- 开发和验证了Nomogram和C5.0决策树模型;使用KHB方法进行调解分析.
主要成果:
- Qi 停滞构成 (QSC) 和 Qi 缺乏构成 (QDC) 被确定为CF的重要风险因素.
- 基于TCMC的预测模型 (C5.0和Nomogram) 显示出强大的预测性能 (AUC>0.81).
- 睡眠质量部分调解了QSC和CF之间的关系 (22.7%的调解).
结论:
- QSC和QDC是认知虚弱的可修改风险因素.
- 基于TCMC的预测模型对CF风险表现出强大的性能和概括性.
- 通过睡眠质量差,QSC可能会加剧CF,突出其作为临床风险分层和预防目标的潜力.
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