系统性青少年异常性关节炎中巨细胞激活综合征的危险因素:系统性审查和元分析
Shihao Li1,2,3, Xin Wu1,2,3, Shuolan Jing1,2,3
1Division of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, China.
Frontiers in pediatrics
|December 22, 2025
概括
在全身性青少年异常性关节炎 (sJIA) 中确定巨细胞激活综合征 (MAS) 的危险因素至关重要. 中枢神经系统的参与,低纤维素素,高费里和白血病是sJIA患者MAS的关键指标.
科学领域:
- 类风湿病学 类风湿病学
- 儿科 儿科 儿科
- 关键护理医学 关键护理医学
背景情况:
- 大细胞激活综合征 (MAS) 是系统性青少年异常性关节炎 (sJIA) 的危及生命的并发症.
- 早期识别MAS风险因素对于降低sJIA患者的死亡率至关重要.
- 关于MAS风险因素的现有证据是异质的,缺乏临床可转化结论.
研究的目的:
- 系统地识别和量化SJIA中MAS的风险因素.
- 为早期MAS检测和管理提供临床相关的见解.
主要方法:
- 在多个数据库 (PubMed,科学网,EMBASE,CNKI,万芳,VIP,CBM) 进行系统的文献搜索,截至2025年7月1日.
- 包括调查SJIA中MAS风险因素的病例控制研究.
- 使用RevMan 5.3和Stata 16.0.0进行的元分析.
主要成果:
- 包括10项涉及1936名患者的研究 (643例,1293例对照).
- 在中枢神经系统 (中枢神经系统) 参与 (OR 4.30),低纤维素生成血症 (OR 4.03),超蛋白血症 (OR 8.28) 和白血病 (OR 5.98) 中发现了显著的关联.
- 这些因素显示出相当大的赔率比率,表明在sJIA中与MAS有很强的关联.
结论:
- 中枢神经系统的干扰,低纤维素生成血,高血和白血病是SJIA中MAS的核心危险因素.
- 这些已识别的因素对于早期风险评估和sJIA患者的及时干预至关重要.
- 这些发现提供了量化和可比的结论,以指导临床实践.
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