在肯尼亚海岸,评估艾滋病毒感染和没有艾滋病毒的成年人的神经认知功能:测量问题和相关性
Patrick N Mwangala1,2,3, Carophine Nasambu2, Ryan G Wagner4
1Institute for Human Development, Aga Khan University, Nairobi, Kenya.
Frontiers in aging neuroscience
|December 22, 2025
概括
肯尼亚艾滋病毒感染老年人的认知查显示,适应的牛津认知屏幕Plus (OCSPlus) 是可接受和可靠的. 结果显示了混合的认知表现和与生物心理社会因素的关联.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 老年学是一门学科.
背景情况:
- 认知障碍是艾滋病毒感染的常见并发症,影响日常功能.
- 包括肯尼亚在内的撒哈拉以南非洲地区缺乏针对艾滋病毒感染者 (PLWH) 的老年人认知评估工具.
- 这种差距阻碍了及时的干预,如精神教育和治疗老年PLWH认知衰退.
研究的目的:
- 适应和评估牛津认知屏幕Plus (OCSPlus) 以评估肯尼亚老年人 (≥50岁) 的认知功能.
- 检查OCSPlus在艾滋病毒感染的老年人及其未感染艾滋病毒的同龄人中的可接受性,可靠性和有效性.
- 在这个人群中探索认知性能差异和相关的生物心理社会因素.
主要方法:
- 一项涉及肯尼亚440名老年人 (257名艾滋病毒感染者) 的横截面研究.
- 适应基于平板电脑的OCSPlus工具的使用.
- 同时使用传统的认知测试 (雷文标准渐进矩阵,国际艾滋病毒痴呆症量表) 和健康/社会人口统计评估.
主要成果:
- 参与者和管理人员对OCSPlus的高度接受度;良好的测试-重新测试可靠性和融合有效性.
- 与未感染艾滋病毒的同龄人相比,感染艾滋病毒的老年人 (OALWH) 在语言和执行功能方面得分较低,但在记忆和处理速度方面表现更好.
- 认知表现与行为,生活方式,社会人口统计学,医学,治疗和心理社会因素有关.
结论:
- 该OCSPlus是一个可行的,可接受的,和初步有效的工具,用于认知查低识字的老年人在肯尼亚.
- 这种人群的认知表现很复杂,结果各异,与各种生物心理社会因素有显著的关联.
- 需要进一步的研究来充分确定OCSPlus的实用性,并了解SSA中艾滋病毒感染的老年人认知功能.
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