肠道微生物群和宿主DNA甲基化之间的相互作用在炎症性肠病的发病和治疗中
Qing Jin1, Xiang Li2, Zhonggui Liu2
1Laboratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Frontiers in microbiology
|December 22, 2025
概括
在炎症性肠病 (IBD) 中研究肠道微生物组和DNA甲基化揭示了关键的分子相互作用. 了解这些途径为精密医学和IBD治疗提供了新的途径.
科学领域:
- 胃肠道学和免疫学
- 表观遗传学和微生物组研究
背景情况:
- 炎症性肠病 (IBD) 是一种复杂的慢性胃肠道疾病,受遗传,环境和免疫因素的影响.
- 肠道微生物群和宿主表观遗传调节之间的相互作用,特别是DNA甲基化,对于理解IBD病原体至关重要.
- 肠道微生物通过代谢副产品影响宿主基因表达和免疫反应,影响肠道屏障功能.
研究的目的:
- 审查控制肠道微生物群与宿主DNA甲基化相互作用的分子机制.
- 检查环境因素如何通过微生物-表观遗传路径影响IBD发病和进展.
- 突出多奥米克发现及其在IBD精准医学中的潜力.
主要方法:
- 文献综述专注于分子机制,环境影响和多omics研究.
- 分析肠道微生物组成,DNA甲基化模式和免疫反应之间的相互作用.
- 对IBD中微生物群-表观遗传通路的当前研究进行综合.
主要成果:
- 肠道微生物群的代谢物调节宿主基因表达和免疫信号.
- 宿主DNA甲基化模式反映和调解微生物失生症的影响.
- 环境因素可以改变肠道微生物组,影响与IBD相关的表观遗传修饰.
结论:
- 肠道微生物群-表观遗传轴是IBD发展和进展的关键决定因素.
- 多omics方法对于破译复杂的IBD分子基础至关重要.
- 针对微生物群-表观遗传相互作用,有望为新的IBD治疗策略和精准医学提供希望.
更多相关视频
相关概念视频
01:29Inflammatory Bowel Disease IV: Pharmacological Management
445
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
445
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
614
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
614
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
859
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
859
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
459
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
459
01:17Irritable Bowel Syndrome I: Introduction
890
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
890
01:30Inflammatory Bowel Disease II: Crohn's Disease
915
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
915