HPV-16,HPV-18基因型与p16表达在头癌中的相关性:西印度的一项研究
Disha D Jethva1, Trushika R Kapadia1, Kinjal K Gajjar1
1Department of Cancer Biology, The Gujarat Cancer and Research Institute, Asarwa, Ahmedabad, Gujarat, India.
South Asian journal of cancer
|December 22, 2025
概括
人类乳头瘤病毒 (HPV) -16感染与印度西部头癌 (HNC) 患者的转移有关. 然而,HPV-16和p16表达没有显著影响这一队列的整体存活率.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 头癌 (HNC) 是一个重要的全球健康问题.
- 人类乳头瘤病毒 (HPV),特别是HPV-16和HPV-18,以及p16表达在HNC病原和预后中的作用正在调查中.
- 对于有针对性的干预措施来说,了解这些不同人群的关联,例如西印度,至关重要.
研究的目的:
- 调查HPV-16,HPV-18感染和p16表达与临床病理参数的临床关联.
- 评估这些标志物与头癌患者的风险行为之间的关系.
- 确定HPV-16,HPV-18和p16表达对西印度HNC队列的生存结果的影响.
主要方法:
- 从2021年至2023年间诊断的92名HNC患者的临床数据的回顾性分析.
- 使用实时聚合酶链反应检测HPV-16和HPV-18感染.
- 通过免疫组织化学评估p16的表达.
- 统计分析以将病毒状态和p16表达与临床病理学参数,风险行为和生存结果相关联.
主要成果:
- 在13%的患者中检测到HPV-16感染;没有发现HPV-18感染.
- 在14%的患者中,p16表达是阳性的.
- 在HPV-16阳性和转移之间观察到显著的关联 (p < 0.001).
- 在HPV-16/p16状态与其他临床病理学参数或风险行为之间没有发现显著的关联.
- 无论是HPV-16感染还是p16表达都不是总体存活的重要预测因素.
结论:
- 这项研究强调了HPV-16感染和西印度HNC患者的转移之间的重要联系.
- 在这个队列中,HPV-18感染和p16表达显示出有限的患病率和没有显著的临床关联.
- 需要进一步的前性研究来验证这些发现,并探索与HPV相关的HNC的治疗含义.
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