从猪身上分离出来的潜在益生菌Ligilactobacillus ruminis CACC881的完整基因组序列
Soyeon Park1, Mi Ae Park1, Hyun-Jun Jang1
1Department of Research and Development, Center for Industrialization of Agricultural and Livestock Microorganisms, Jeongeup 56212, Korea.
Journal of animal science and technology
|December 22, 2025
概括
利吉拉克托巴西勒斯鲁米尼斯 (Ligilactobacillus ruminis) CACC881由于其独特的酸/胆盐耐受性和抗氧化活性基因,显示出作为益生菌的潜力. 这项基因组研究为其在动物工业中的应用提供了洞察力.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 益生菌 益生菌 益生菌
背景情况:
- 肠杆菌 (Ligilactobacillus ruminis) 是一种在肠道中发现的未经研究的无氧细菌.
- 对L. ruminis的基因组数据有限,这阻碍了对其益生菌潜力的理解.
研究的目的:
- 为了分析L. ruminis CACC881的基因组,寻找潜在的益生菌特性.
- 为了对五种L. ruminis菌株进行比较基因组分析.
主要方法:
- 在L. ruminis CACC881.1.的全基因组测序.
- 生物信息分析用于预测基因功能.
- 跨多个L. ruminis菌株的比较基因组学.
主要成果:
- 在L. ruminis CACC881基因组 (2,107,343 bp) 中包含了1935个编码蛋白质的基因.
- 确定了与酸/胆盐耐受性,CRISPR和维生素B相关的基因.
- 针对细菌素调节/免疫 (nisK,nisI) 和抗氧化活性 (ahpC) 的独特基因仅在CACC881.1.菌株中发现.
结论:
- L. ruminis CACC881 具有独特的遗传特征,表明它具有显著的益生菌潜力.
- 鉴定的基因支持其在动物工业中的潜在应用.
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