慢性阻塞性肺病患者多种长期疾病的临床研究变量推导和定义:为修改的德尔菲方法和国际心血管和呼吸系统联盟代表的共识研究的议定书
Tobin Joseph1,2,3, Mohit Bhutani4, Amy Couper5,6
1Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Pragmatic and observational research
|December 22, 2025
概括
本研究概述了一种方法来定义慢性阻塞性肺病 (COPD) 患者的关键临床变量,这些患者有多种健康状况. 其目标是改善临床研究报告和质量改善举措.
科学领域:
- 临床研究方法论 临床研究方法论
- 肺部病理学 肺部病理学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 标准化变量和定义对于可靠的临床研究和慢性阻塞性肺病 (COPD) 的质量改善至关重要.
- 本协议解决了在经历多病症或高风险的COPD患者中定义临床研究变量的需要.
- 建立一致的数据点对于推进COPD护理和研究至关重要.
研究的目的:
- 描述 COPD 多病症患者的临床研究变量推导和定义的理由和方法.
- 建立一个标准化的变量集,以便在COPD研究中进行一致的数据收集和报告.
- 促进更好的质量改进计划和COPD临床试验结果的改善.
主要方法:
- 一个由四个步骤组成的过程,涉及执行委员会,指导委员会和国际共识小组.
- 系统的文献审查,以确定和提出潜在的临床研究变量定义.
- 修改了Delphi流程,具有代投票和委员会之间的反,以在变量和定义上达成共识.
主要成果:
- 为COPD开发最终一套国际商定的,分层分类的临床研究变量.
- 通过达成共识,完善选择的候选临床研究变量的定义.
- 建立一个标准化的框架,用于临床研究中选择COPD的变量.
结论:
- 由此产生的变量和定义将提高COPD临床研究和质量改进工作的可靠性.
- 预计这种标准化的方法将改善COPD研究中的数据一致性和可比性.
- 这些发现将通过同行评审的出版物和演讲传播,以告知科学界.
相关概念视频
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.1K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.1K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
3.5K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.5K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
3.5K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.5K
01:20COPD: Pathogenesis and Clinical Features
1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
01:22Chronic Obstructive Pulmonary Disease
2.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.2K
01:26Longitudinal Studies
444
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
444