全球趋势和神经退行性疾病菌的前景:超过20年的科学分析分析
Haiyan Wu1, Minheng Zhang2, Lei Zhang1
1First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Frontiers in medicine
|December 22, 2025
概括
这项研究映射了神经退行性疾病中线粒细胞衰变的研究,揭示了指数增长和帕金森病和线粒体功能障碍等关键主题. 这些研究结果支持开发针对线粒功能障碍的新疗法.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 在神经退行性疾病中对线粒细胞衰变的研究迅速扩大.
- 目前对这一研究领域的全面全球概述是有限的.
- 这项研究提供了一个科学测量分析来绘制该领域的地图.
研究的目的:
- 对神经退行性疾病中线粒细胞衰变的全球研究进行科学测量分析.
- 绘制该研究领域的演变,关键主题和新兴趋势的地图.
- 识别有影响力的研究人员,机构和出版物.
主要方法:
- 从2004年到2025年6月,对2566篇出版物的图书统计分析 (科学核心集合和Scopus的网络).
- 数据使用Bibliometrix R包,VOSviewer,Scimago Graphica和CiteSpace.Space进行分析.
- 通过集群分析确定的主题结构.
主要成果:
- 该领域经历了指数式增长,在2021年达到顶峰,美国是主要贡献者.
- 关键的研究主题包括帕金森病,线粒体功能障碍,氧化应激和帕金森介导的线粒.
- 新兴趋势包括翻译后修改,肠道微生物群,线粒体质量控制以及黄素和黑激素等治疗方法.
结论:
- 这种科学测量分析突出显示了人们对神经退行性疾病中菌体的作用越来越感兴趣.
- 这些发现为开发针对线粒功能障碍的新型治疗干预提供了框架.
- 潜在的疗法包括线粒体质量控制调节剂和黄素和黑激素等化合物.
相关概念视频
01:37Mitochondria
19.5K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
19.5K
01:19Translocation of Proteins into the Mitochondria
11.8K
Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
11.8K
01:45Mitochondrial Membranes
16.5K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
16.5K
01:46Electron Transport Chain: Complex I and II
18.3K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
18.3K
01:27Autophagy
5.6K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.6K
02:59Animal Mitochondrial Genetics
8.9K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
8.9K