流行病学趋势和病爆发的决定因素:系统审查和元分析
Ritik Agrawal1,2, Tanveer Rehman1,2, Deepti Sinha1
1ICMR Regional Medical Research Centre, Bhubaneswar, Odisha, India.
Frontiers in public health
|December 22, 2025
概括
爆发是一个全球性的问题,成年人经历了最高的攻击率 (ARs). 建议使用第三剂MMR疫苗,以减少发病的发生率和并发症.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 尽管疫苗接种广泛,但疹疫情在全球范围内正在复苏.
- 这项研究解决了了解当前疹流行病学和结果的需要.
研究的目的:
- 在全球范围内对疹疫情进行系统审查和元分析.
- 评估流行病学特征,攻击率 (ARs) 和并发症率.
- 为了确定与发病爆发相关的趋势和风险因素.
主要方法:
- 在MEDLINE,Embase,CINAHL和谷歌学者中系统搜索研究 (2004-2024年).
- 包括所有年龄组符合世卫组织标准的确诊病例.
- 使用随机效应模型对AR和并发症率的聚合分析;执行子组和元回归分析.
主要成果:
- 分析了来自21个国家的47项研究,其中包括71,174例病例.
- 聚合性疹爆发的AR为14.5%,成年人呈现最高的AR (31.8%).
- 综合并发症率为10.3%,炎最常见 (63.1%);在美洲和东地中海地区观察到更高的AR.
结论:
- 由于疫苗免疫力下降,疹疫情在全球范围内持续存在.
- 建议在疫苗接种计划中使用第三次麻疹,疹和红疹 (MMR) 强剂量.
- 对高风险群体来说,增强剂特别重要,以减轻AR和并发症.
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