青春期出现的初级Sjögren综合征:一个病例报告
Sutlan Albaqawi1, Ahmed Alanazi1, Ruqayyah H Almarshadi1
1Oral and Maxillofacial Surgery, King Khalid Hospital, Hail, SAU.
Cureus
|December 22, 2025
概括
儿童早期发病的原发性Sjögren综合征很少见,经常出现不寻常的症状,如胀的唾液腺和口腔干燥. 通过唾液腺活检支持的早期诊断对于防止永久性损伤至关重要.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 自免疫性疾病 自免疫性疾病
- 斯乔格伦综合征研究研究
背景情况:
- 主要Sjögren综合征 (pSS) 是一种自身免疫疾病,主要影响成年人.
- 儿科患者早期发病的pSS异常罕见,经常出现异常症状.
- 儿童的诊断延迟可能导致严重的发病率,包括不可逆转的腺体损伤和全身并发症.
研究的目的:
- 在儿科患者中报告早期出现的原发性Sjögren综合征病例.
- 突出儿童PSS的诊断挑战和微妙的临床特征.
- 强调早期识别的重要性以及小唾液腺活检在诊断中的作用.
主要方法:
- 一个14岁的女性的病例报告显示,她患有膜胀和口腔干燥.
- 图像分析包括唾液腺的对比增强计算机断层扫描 (CT).
- 细微的唾液腺活检的组织病理学检查.
主要成果:
- 患者表现出双侧膜胀和口腔干燥.
- 扫描显示了扩散的腺体扩大,有点点的放射性斑点焦点.
- 微小的唾液腺活检证实了焦点淋巴细胞腺炎 (大约. 50淋巴细胞/HPF) 和轻微的状缩.
结论:
- 小儿原发性Sjögren综合征需要高度的临床怀疑,因为它的罕见性和不典型的表现.
- 小唾液腺活检是确认儿童诊断的宝贵工具.
- 早期识别和干预对于缓解长期并发症至关重要.
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