为胆囊疾病进行胆囊切除术的患者中细菌菌的患病率:一项观察性研究
Naveen Naik Mude1, Shanmugam Dasarathan1, Sudharsanan Sundaramurthi1
1Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IND.
Cureus
|December 22, 2025
概括
细菌 (胆汁中的细菌) 影响了印度超过一半接受胆囊手术的患者,主要是大肠杆菌. 虽然对常见抗生素的耐药性正在上升,但阿米卡辛和美罗仍然有效,指导未来的治疗策略.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 外科手术的结果
背景情况:
- 胆汁中的细菌 (bactibilia) 是胆囊切除术患者的一个问题,可能导致并发症.
- 有限的数据存在于印度的bactibilia流行,微生物形状和抗生素耐药性.
- 这项研究解决了印度接受胆囊手术的患者对细菌菌的知识差距.
研究的目的:
- 为了确定在印度南部接受胆囊切除术的患者中细菌菌的患病率.
- 为了识别导致bactibilia的常见细菌分离物.
- 评估这些分离物的抗微生物敏感性模式.
主要方法:
- 一项涉及121名在南印度接受间隔胆囊切除术的患者的横截面研究.
- 在手术期间的胆汁样本中培养了有氧和无氧细菌.
- 进行了抗生素敏感性测试和30天的术后结果监测,包括手术部位感染 (SSIs).
主要成果:
- 在57.9%的患者中检测到细菌,在女性和51-60岁的人群中更为常见.
- 大肠杆菌 (62.0%) 和 Acinetobacter baumannii (11.4%) 是主要的分离物.
- 格拉姆阴性细菌对素和基诺具有很高的耐药性,但对阿米卡辛和美罗胺仍然敏感.
结论:
- 在接受胆囊切除术的印度患者中,细菌菌的发病率很高,主要是大肠杆菌和Acinetobacter.
- 新兴的抗菌素耐药性需要经由局部抗生素图指导,仔细选择抗生素.
- 需要进一步的研究来优化胆囊手术的抗生素预防.
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