与慢性腹膜下血瘤的进展和性别特异性模式相关的因素:单中心回顾性研究
Weijian Yang1,2,3,4,5, Zhuoying Du1,2,3,4,5, Qifang Chen1,2,3,4,6
1Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Frontiers in neurology
|December 22, 2025
概括
慢性亚皮血瘤 (CSDH) 的进展与高的INR,高血压,糖尿病,NLR,WBC和最大血瘤密度有关. 女性似乎对CSDH的进展有保护作用,这需要进一步调查.
科学领域:
- 神经外科 神经外科
- 神经学 神经学
- 内部医学 内部医学
背景情况:
- 慢性亚皮血瘤 (CSDH) 是一种常见的神经外科疾病,特别是在老年患者中.
- 了解影响CSDH进展的因素对于有效的管理和治疗策略至关重要.
- 关于CSDH发育和进展的潜在性别相关差异仍然是积极研究的领域.
研究的目的:
- 为了确定慢性腹腔内血瘤 (CSDH) 进展的独立预测因子.
- 研究与CSDH进展相关的因素的潜在性别特异性差异.
- 为了更好地了解CSDH的病理生理学.
主要方法:
- 对1,142名单边CSDH患者的回顾性分析.
- 数据收集包括人口统计,临床特征,血液瘤密度和血液学参数.
- 采用多变量逻辑回归和队列分析来确定进展的独立预测因素.
主要成果:
- CSDH进展的独立风险因素包括国际正常化比率 (INR) 升高,高血压,糖尿病,中性粒细胞与淋巴细胞比率 (NLR),白细胞计数 (WBC) 和最大血瘤密度 (MaHD).
- 女性性别被认为是预防CSDH进展的重要保护因素.
- 亚组分析显示血红蛋白,血清白蛋白和血小板计数的性别特异性差异,尽管值保持在正常范围内.
结论:
- 升高的INR,高血压,糖尿病,NLR,WBC和MAHD独立地与CSDH进展有关.
- 女性表现出对CSDH进展的保护作用.
- 需要对这些发现进行前性验证,以确认它们的临床意义.
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