体重指数与男性的精子质量和性激素有关:一个元分析
Fengming Ji1,2, Bing Yan2, Chenghao Zhanghuang2
1Urology Surgery Department Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, China.
Frontiers in endocrinology
|December 22, 2025
概括
体重指数 (BMI) 升高会对男性生育能力产生负面影响,影响精子质量和性激素水平. 这凸显了BMI作为男性生育能力评估的关键因素.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 安德罗学与人类学
- 公共卫生 公共卫生
背景情况:
- 肥胖和超重是全球性的健康问题.
- 体重指数 (BMI) 是评估体重状况的常见指标.
- 体重指数对男性生殖健康的影响需要进行系统的评估.
研究的目的:
- 系统地评估体质指数 (BMI) 和精子质量参数之间的关系.
- 评估男性的BMI和性激素水平之间的关联.
- 为了确定BMI是否是男性不孕症的危险因素.
主要方法:
- 在主要数据库 (PubMed,Embase,Cochrane,CNKI,Wanfang) 中进行全面的文献搜索.
- 包括对成人男性 (>18岁) 的研究,检查BMI和精液参数或性激素.
- 使用RevMan 5.4和Stata 18.0对14项符合条件研究的数据进行了元分析,涉及8443名参与者.
主要成果:
- 在正常,超重和肥胖的BMI群体中观察到精子质量参数的显著差异,包括正常形态,总运动率,精子度,渐进运动率,体积和总精子数.
- 在BMI组中发现了性激素水平的统计显著差异,包括总丸激素,卵泡刺激激素和黄素化激素.
- 较高的BMI与精子质量受损和变化的性激素配置文件有关.
结论:
- 较高的BMI与男性的精子质量降低和异常性激素水平显著相关.
- 在评估男性生育能力时,BMI应被视为一个重要的风险因素.
- 建议进行进一步的研究,包括纵向研究,以调查生活方式干预措施扭转这些不良影响的潜力.
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